Impurities & Specialized Compounds

Small Molecule API/Pharmaceutical Development

With over 30 years of hands-on experience in pharmaceutical drug discovery and developments, we assist customers with synthetic route scouting/development and optimization, as well as early-process scale-up of API targets, biosimilar, and drug-like molecules.

Research and Development

We work closely with partners throughout their complete drug discovery and development program, including parenteral drug discovery. With our extensive experience in pharmaceutical and biotechnology research and development, we help customers speed up in the synthetic route scouting and optimization of the most complex small molecules, from milligrams to kilograms in our R&D facility. We also offer expertise to those developing unique products that are challenging to formulate. 

Catalogue Compounds

JSI Research offers many drug impurities and pharmaceutical reference standards. We also specialize in Nitrosamines, Peptides, PET tracers, and many others. Additionally, our inventory has an extensive range of research chemical compounds, including reference materials, process impurities, degradants & metabolites of APIs, natural products, diagnostic imaging reagents, and various chemical building blocks. Please see our inventory.

Certificate of Analysis (CoA) 

We confirm the purity of the product by giving you a certificate of analysis (COA). In our COA, we include HPLC, NMR, MS, FT-IR, water and residual solvent content, and other assays if requested. Please note that all purities are given on a dry basis. Purity does not include water or solvent that may be present. These quantities will be listed separately on the COA when applicable.

Impurities and Specialized products

The root of impurities in pharmaceutical drugs are from various sources and phases of synthetic processes, and the development of pharmaceutical dosage forms. The bulk of impurities are characteristics of the relevant synthetic route of the manufacturing process. There are numerous paths to synthesizing a drug, it is possible that the identical product of different sources can produce different impurities. With over 20 years of experience in pharmaceutical APIs and impurities, we can offer custom synthesis of complex organic compounds for use as pharmaceuticals standards, impurities, degradation products and other drug-like molecules for pharmaceutical and bio-medical industries with uncompromised quality. Please see our inventory.

Small-scale Process Research and Scale-up

With our expertise in pharmaceutical process development, we can quickly and efficiently scale up your requested compounds in our R&D facility. Even if you require a “difficult to almost impossible to achieve” target API/standard/drug-like molecule, we are looking to take your APIs to a large scale (multi-kilogram). We provide you with an effective solution and easy to follow procedure to keep your program moving.

Tailored Biomedical Polymers

We have more than 20 years of hands-on experience in synthesizing biodegradable polymers, novel polymers for biomedical applications, and hydrogels for safe drug delivery. These materials have various medical device applications (ISO13485).  Over the decades, we have been engaged in developing several major innovative procedures, including new hydrogels and silicone photopolymer initiators, ionomers, anti-biofouling polymers, functionalized biopolymers, emulsions and nano-emulsions, coagulants and flocculants, biopolymers for liquid Redox Sulfer Recovery (LRSR) process, wound-healing polymers, and antibody discoveries, among many others.

Integrated Solutions

We offer full-spectrum solutions that combine small molecule API development and large polymers for delivery purposes. JSI offers powerful integrated solutions that combine our expertise in small molecule chemistry with our expertise in tailored large molecule design for drug delivery and medical device applications. We truly bridge the gap between small molecule and large molecule & polymer synthesis by making your new technology unique from the very first generation of its design.When you choose JSI products, you choose a high-quality reference standard manufactured in a well-regulated laboratory to achieve your highest testing accuracy.

Metabolites

Metabolites could be a drug, dietary supplement, or other substance. Metabolites may contain active ingredients that can be beneficial or harmful. They may also measure a drug’s effectiveness or monitor drug toxicity. We have extensive experience in metabolite research, and we have already developed a broad range of metabolites in our inventory that can help our customers study various metabolic events and disorders. Please see our inventory.

Conjugates

Antibody–drug conjugate (ADC) is composed of a monoclonal antibody (mAbs) which is covalently attached to a cytotoxic drug via a chemical linker. It constitutes both the advantages of the highly specific targeting ability and, at the same time, a highly potent killing effect to yield accurate and efficient elimination of cancer cells. This has become one of the hotspots for the research and development of many drugs, particularly anticancer drugs. We are specialists in antibody development, purification, and the study of antibody-drug conjugates (ADC).

Labelled Compounds

‍Labelled compounds are used as a reference for internal standards in drug testing and research. They can also identify and characterize drug product impurities and monitor drug purity and consistency. We have many labelled compounds in our inventory.

Nucleic acids, Amino acids and lipid/lipidoids

Lipid nanoparticles (LNPs) have been playing an integral role in mRNA vaccines against COVID-19. In addition, many preclinical and clinical studies, including the siRNA-LNP product, highlight that LNPs unlock the potential of nucleic acid-based therapies and vaccines. With our speciality in LNPs, we help customers with many building blocks that constitute them. Please check our inventory.

Fuel-cell catalysts

We are also experts in electrocatalysts and technologies that can provide ultra-low loading of Pt-based catalysts. These nano-sized particles are very suitable for the fast production of hydrogen fueled clean energy. With our commitment to clean energy and the environment, we offer customers stable, effective, and innovative nano-sized solid-supported fuel-cell catalysts (pfc) and related technologies.

Nitrosamines

‍Nitrosamines are carcinogenic and are primarily present in API, processed meats and personal care products. We have a large number of nitrosamine compounds in our inventory. Please see our inventory.

Biodegradable Polymers & Ionomers

The biodegradable synthetic polymers are man-made materials that are highly useful in the biomedical field because of their properties associated with tissue engineering applications. Synthetic polymers indeed show physicochemical and mechanical properties suitably comparable to those of biological tissues. For our ongoing dedication to environmental protection and green chemistry, we aim to help customers grow products in the fields of biodegradable polymers and ionomers for their manifold environmental-friendly application.